Impact of GLP-1 Receptor Agonists on Immune Function and Vaccine Response

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), like semaglutide, are widely used for managing diabetes and weight loss. However, their extended use raises concerns about their impact on immune responses, particularly vaccine efficacy. Unlike natural GLP-1, GLP-1RAs have longer half-lives and are administered at higher concentrations, potentially affecting immune cells beyond the pancreas.