Causes, Risks, and Treatment of Early Morning Hyperglycemia in Diabetes

The dawn phenomenon (DP) refers to early morning hyperglycemia in individuals with diabetes or prediabetes, typically occurring between 3:00 and 8:00 AM, without prior nocturnal hypoglycemia. It impacts up to 55% of those with type 2 diabetes and is linked to poorer outcomes, including higher A1c levels and increased risks of heart and kidney disease.

Glycemic Control in Chronic Kidney Disease

In healthy individuals, glucose is filtered at the glomerulus, with most reabsorbed by sodium-glucose cotransporters (SGLT2 and SGLT1) in the proximal tubule. Kidney disease can impair this process, reducing the ability to filter and reabsorb glucose, potentially causing hyperglycemia or hypoglycemia.